- Antibodies
- New
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Tag
- Peptides
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Amino Acids
- Tag
- Biological Process >
- Proteins
- RNAi
- FL cDNA Clones
- Cell/Tissues/Lysates
ROBO3 / RIG1 (internal) AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
Australia Austria Belgium Brazil Bulgaria Canada China Croatia Cyprus Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland India Indonesia Ireland Israel Italy Japan Korea Latvia Lithuania Luxembourg Macedonia Malaysia Malta Netherlands Norway Pakistan Poland Portugal Romania Serbia Singapore Slovakia Slovenia Spain Sweden Switzerland Taiwan Turkey United Kingdom United States Vietnam Others 
|
|||
|---|---|---|---|---|
| Catalog # | Size | Availability | Price | |
| AF1941a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ROBO3 / RIG1 (internal) Antibody - Product info | |
| Other Accession | NP_071765 |
| Reactivity | Human |
| Concentration | 100ug/200ul |
| Isotype | IgG |
ROBO3 / RIG1 (internal) Antibody - Additional info | |
| Other Names ROBO3; RIG1; roundabout, axon guidance receptor, homolog 3 (Drosophila) ; FLJ21044; HGPPS; RBIG1; retinoblastoma inhibiting gene 1; roundabout, axon guidance receptor, homolog 3 | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ROBO3 / RIG1 (internal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
ROBO3 / RIG1 (internal) Antibody - Application data
-
AF1941a (0.5 µg/ml) staining of Human Brain (Cerebellum) lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
ROBO3 / RIG1 (internal) Antibody - Related products
Abgent welcomes feedback from its customers.
If you have used an Abgent product and would like to share how it has performed, please click on the
"Submit Review" button and provide the requested information. Our staff will examine and post your
review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.
Thank you for your support.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.
REFERENCES
Bilateral synergistic convergence associated with homozygous ROB03 mutation (p.Pro771Leu). Khan AO, et al. Ophthalmology, 2008 Dec. PMID 19041479. Five new consanguineous families with horizontal gaze palsy and progressive scoliosis and novel ROBO3 mutations. Abu-Amero KK, et al. J Neurol Sci, 2009 Jan 15. PMID 18829051. Genetic analyses of roundabout (ROBO) axon guidance receptors in autism. Anitha A, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Oct 5. PMID 18270976. Association study between Gilles de la Tourette Syndrome and two genes in the Robo-Slit pathway located in the chromosome 11q24 linked/associated region. Miranda DM, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Jan 5. PMID 17671968. Horizontal gaze palsy with progressive scoliosis can result from compound heterozygous mutations in ROBO3. Chan WM, et al. J Med Genet, 2006 Mar. PMID 16525029.
