|Application ||WB, IHC, E|
|Other Accession||NP_062427, 6275, 20198 (mouse), 24615 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||11729 Da|
|Other Names||Protein S100-A4, Calvasculin, Metastasin, Placental calcium-binding protein, Protein Mts1, S100 calcium-binding protein A4, S100A4, CAPL, MTS1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-S100A4 / CAPL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
S100 proteins interact with the N-terminal domain of MDM2. van Dieck J, et al. FEBS Lett, 2010 Aug 4. PMID 20591429.
Overexpression of S100A4 in human cancer cell lines resistant to methotrexate. Menc铆a N, et al. BMC Cancer, 2010 Jun 1. PMID 20515499.
S100A4 expression is increased in stricture fibroblasts from patients with fibrostenosing Crohn's disease and promotes intestinal fibroblast migration. Cunningham MF, et al. Am J Physiol Gastrointest Liver Physiol, 2010 Aug. PMID 20489045.
Subcellular distribution of S100A4 and its transcriptional regulation under hypoxic conditions in gastric cancer cell line BGC823. Zhang R, et al. Cancer Sci, 2010 May. PMID 20367639.
Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. Roberts KE, et al. Gastroenterology, 2010 Jul. PMID 20346360.
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