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Goat Anti-SAR1B / SARA2 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-SAR1B / SARA2 Antibody AF1958a
    AF1958a (0.03 µg/ml) staining of Mouse Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • WB - Goat Anti-SAR1B / SARA2 Antibody AF1958a
    HEK293 overexpressing SAR1B (RC210593) and probed with AF1958a (mock transfection in first lane), tested by Origene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y6B6
Other Accession NP_057187, 51128, 66397 (mouse), 287276 (rat)
Reactivity Mouse, Rat
Predicted Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 22410 Da
Additional Information
Gene ID 51128
Other Names GTP-binding protein SAR1b, GTP-binding protein B, GTBPB, SAR1B, SARA2, SARB
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SAR1B / SARA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SAR1B
Synonyms SARA2, SARB
Function Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.
Cellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.
Tissue Location Expressed in many tissues including small intestine, liver, muscle and brain
Research Areas
Citations (0)

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The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene.


Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 gene. Cefal霉 AB, et al. Metabolism, 2010 Apr. PMID 19846172.
Anderson's disease (chylomicron retention disease): a new mutation in the SARA2 gene associated with muscular and cardiac abnormalities. Silvain M, et al. Clin Genet, 2008 Dec. PMID 18786134.
Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
Anderson or chylomicron retention disease: molecular impact of five mutations in the SAR1B gene on the structure and the functionality of Sar1b protein. Charcosset M, et al. Mol Genet Metab, 2008 Jan. PMID 17945526.
Expression of Sara2 human gene in erythroid progenitors. Jardim DL, et al. J Biochem Mol Biol, 2005 May 31. PMID 15943909.

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$ 325.00
Cat# AF1958a
(40 western blots)
Availability: 7-10 days
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