|Application ||WB, IF, ICC, E|
|Other Accession||NP_663327, 8578|
|Calculated MW||87387 Da|
|Other Names||Scavenger receptor class F member 1, Acetyl LDL receptor, Scavenger receptor expressed by endothelial cells 1, SREC-I, SCARF1, KIAA0149, SREC|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-SCARF1 / SREC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells and mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Transcription factors ZNF444/EZF-2 and SP1 are found to be responsible for the regulation of this gene. Five alternatively spliced transcript variants encoding distinct isoforms have been described.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. Berwin B, et al. J Biol Chem, 2004 Dec 3. PMID 15371419.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain. Ishii J, et al. J Biol Chem, 2002 Oct 18. PMID 12154095.
Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2. Adachi H, et al. J Biol Chem, 2002 Jul 5. PMID 11978792.
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