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Goat Anti-SEL1L Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-SEL1L Antibody AF1966a
    AF1966a (1 µg/ml) staining of HepG2 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UBV2
Other Accession NP_005056, 6400, 20338 (mouse), 314352 (rat)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 88755 Da
Additional Information
Gene ID 6400
Other Names Protein sel-1 homolog 1, Suppressor of lin-12-like protein 1, Sel-1L, SEL1L, TSA305
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SEL1L Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEL1L
Synonyms TSA305
Function Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in pancreas.
Research Areas
Citations (0)
citation

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References

Identification of type 2 diabetes-associated combination of SNPs using support vector machine. Ban HJ, et al. BMC Genet, 2010 Apr 23. PMID 20416077.
A luminal flavoprotein in endoplasmic reticulum-associated degradation. Riemer J, et al. Proc Natl Acad Sci U S A, 2009 Sep 1. PMID 19706418.
EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex. Cormier JH, et al. Mol Cell, 2009 Jun 12. PMID 19524542.
Functional characterization of two secreted SEL1L isoforms capable of exporting unassembled substrate. Cattaneo M, et al. J Biol Chem, 2009 Apr 24. PMID 19204006.
Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome-dependent manner. Oresic K, et al. Biosci Rep, 2009 Jun. PMID 18811591.

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$ 341.00
Cat# AF1966a
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