|Application ||WB, E|
|Other Accession||NP_005056, 6400, 20338 (mouse), 314352 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||88755 Da|
|Other Names||Protein sel-1 homolog 1, Suppressor of lin-12-like protein 1, Sel-1L, SEL1L, TSA305|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-SEL1L Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in pancreas.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Identification of type 2 diabetes-associated combination of SNPs using support vector machine. Ban HJ, et al. BMC Genet, 2010 Apr 23. PMID 20416077.
A luminal flavoprotein in endoplasmic reticulum-associated degradation. Riemer J, et al. Proc Natl Acad Sci U S A, 2009 Sep 1. PMID 19706418.
EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex. Cormier JH, et al. Mol Cell, 2009 Jun 12. PMID 19524542.
Functional characterization of two secreted SEL1L isoforms capable of exporting unassembled substrate. Cattaneo M, et al. J Biol Chem, 2009 Apr 24. PMID 19204006.
Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome-dependent manner. Oresic K, et al. Biosci Rep, 2009 Jun. PMID 18811591.
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