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Goat Anti-SLC24A5 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q71RS6 |
| Other Accession | NP_995322, 283652, 317750 (mouse) |
| Reactivity | Mouse, Rat |
| Predicted | Human, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 54888 Da |
| Gene ID | 283652 |
|---|---|
| Other Names | Sodium/potassium/calcium exchanger 5, Na(+)/K(+)/Ca(2+)-exchange protein 5, Solute carrier family 24 member 5, SLC24A5, JSX, NCKX5 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-SLC24A5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC24A5 {ECO:0000303|PubMed:16357253, ECO:0000312|HGNC:HGNC:20611} |
|---|---|
| Function | Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+) (PubMed:18166528). Involved in pigmentation, possibly by participating in ion transport in melanosomes (PubMed:16357253, PubMed:18166528). Predominant sodium-calcium exchanger in melanocytes (PubMed:16357253, PubMed:18166528). |
| Cellular Location | Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Melanosome. Note=Enriched in late-stage melanosomes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the potassium-dependent sodium/calcium exchanger family and encodes an intracellular membrane protein with 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments. Sequence variation in this gene has been associated with differences in skin pigmentation.
References
A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. Meda SA, et al. Neuroimage, 2010 Nov 15. PMID 19944766.
Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians. Nan H, et al. Int J Cancer, 2009 Aug 15. PMID 19384953.
Determination of genetic predisposition to patent ductus arteriosus in preterm infants. Dagle JM, et al. Pediatrics, 2009 Apr. PMID 19336370.
Birth prevalence and mutation spectrum in danish patients with autosomal recessive albinism. Gr脼nskov K, et al. Invest Ophthalmol Vis Sci, 2009 Mar. PMID 19060277.
Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5, and OCA2/P loci. Cook AL, et al. J Invest Dermatol, 2009 Feb. PMID 18650849.
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