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Goat Anti-SLC6A4 / 5HTT / SERT Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-SLC6A4 / 5HTT / SERT Antibody AF1999a
    AF1999a (2 µg/ml) staining of Human Colon lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P31645
Other Accession NP_001036, 6532
Reactivity Human, Rat
Predicted Mouse
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 70325 Da
Additional Information
Gene ID 6532
Other Names Sodium-dependent serotonin transporter, 5HT transporter, 5HTT, Solute carrier family 6 member 4, SLC6A4, HTT, SERT
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SLC6A4 / 5HTT / SERT Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC6A4
Synonyms HTT, SERT
Function Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Cellular Location Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin
Tissue Location Expressed in platelets (at protein level).
Research Areas
Citations (0)

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This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.


Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): Association and interaction with childhood trauma and parenting. Blaya C, et al. Neurosci Lett, 2010 Sep 10. PMID 20817074.
Serotonin transporter polymorphism as a predictor for escitalopram treatment of major depressive disorder comorbid with alcohol dependence. Muhonen LH, et al. Psychiatry Res, 2010 Aug 26. PMID 20800901.
Evidence for plasticity genotypes in a gene-gene-environment interaction: the TRAILS study. Nederhof E, et al. Genes Brain Behav, 2010 Aug 4. PMID 20738408.
[Interaction effect of serotonin transporter gene and brain-derived neurotrophic factor on the platelet serotonin content in stroke patients] . Zh Nevrol Psikhiatr Im S S Korsakova, 2010. PMID 20738025.
Association between serotonin transporter polymorphisms and problem behavior in adult males with intellectual disabilities. May ME, et al. Brain Res, 2010 Aug 21. PMID 20735998.

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$ 325.00
Cat# AF1999a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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