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Goat Anti-SLC7A11 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-SLC7A11 Antibody AF2000a
    AF2000a (0.02 µg/ml) staining of Human Spleen lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UPY5
Other Accession NP_055146, 23657
Reactivity Human, Rat
Predicted Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 55423 Da
Additional Information
Gene ID 23657
Other Names Cystine/glutamate transporter, Amino acid transport system xc-, Calcium channel blocker resistance protein CCBR1, Solute carrier family 7 member 11, xCT, SLC7A11
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SLC7A11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC7A11
Function Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.
Cellular Location Membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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SLC7A11 is a member of a heteromeric Na(+)-independent anionic amino acid transport system highly specific for cystine and glutamate. In this system, designated system Xc(-), the anionic form of cystine is transported in exchange for glutamate.


Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines. Pham AN, et al. J Pharmacol Exp Ther, 2010 Mar. PMID 20007406.
Decreased expression of the active subunit of the cystine/glutamate antiporter xCT is associated with loss of heterozygosity of 1p in oligodendroglial tumours WHO grade II. Stockhammer F, et al. Histopathology, 2009 Jan. PMID 19207949.
Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression. Lewerenz J, et al. J Biol Chem, 2009 Jan 9. PMID 19017641.
Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway. Chen RS, et al. Oncogene, 2009 Jan 29. PMID 19015640.

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$ 325.00
Cat# AF2000a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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