|Application ||WB, E|
|Other Accession||NP_055146, 23657|
|Calculated MW||55423 Da|
|Other Names||Cystine/glutamate transporter, Amino acid transport system xc-, Calcium channel blocker resistance protein CCBR1, Solute carrier family 7 member 11, xCT, SLC7A11|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-SLC7A11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.|
|Cellular Location||Membrane; Multi-pass membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SLC7A11 is a member of a heteromeric Na(+)-independent anionic amino acid transport system highly specific for cystine and glutamate. In this system, designated system Xc(-), the anionic form of cystine is transported in exchange for glutamate.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines. Pham AN, et al. J Pharmacol Exp Ther, 2010 Mar. PMID 20007406.
Decreased expression of the active subunit of the cystine/glutamate antiporter xCT is associated with loss of heterozygosity of 1p in oligodendroglial tumours WHO grade II. Stockhammer F, et al. Histopathology, 2009 Jan. PMID 19207949.
Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression. Lewerenz J, et al. J Biol Chem, 2009 Jan 9. PMID 19017641.
Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway. Chen RS, et al. Oncogene, 2009 Jan 29. PMID 19015640.
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