Goat Anti-SLIMMER / FHL1 isoform B Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q13642 |
Other Accession | AAC72886.1, 2273 |
Reactivity | Human |
Predicted | Mouse, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 100ug/200ul |
Isotype | IgG |
Calculated MW | 36263 Da |
Gene ID | 2273 |
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Other Names | Four and a half LIM domains protein 1, FHL-1, Skeletal muscle LIM-protein 1, SLIM, SLIM-1, FHL1, SLIM1 |
Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-SLIMMER / FHL1 isoform B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FHL1 |
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Synonyms | SLIM1 |
Function | May have an involvement in muscle development or hypertrophy. |
Cellular Location | [Isoform 1]: Cytoplasm. [Isoform 2]: Nucleus. Cytoplasm, cytosol. Note=Predominantly nuclear in myoblasts but is cytosolic in differentiated myotubes |
Tissue Location | Isoform 1 is highly expressed in skeletal muscle and to a lesser extent in heart, placenta, ovary, prostate, testis, small intestine, colon and spleen. Expression is barely detectable in brain, lung, liver, kidney, pancreas, thymus and peripheral blood leukocytes. Isoform 2 is expressed in brain, skeletal muscle and to a lesser extent in heart, colon, prostate and small intestine. Isoform 3 is expressed in testis, heart and skeletal muscle |
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Background
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.
References
Contractures and hypertrophic cardiomyopathy in a novel FHL1 mutation. Knoblauch H, et al. Ann Neurol, 2010 Jan. PMID 20186852.
Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface protein. Luo S, et al. Mol Immunol, 2009 Dec. PMID 19850343.
Mutations of the FHL1 gene cause Emery-Dreifuss muscular dystrophy. Gueneau L, et al. Am J Hum Genet, 2009 Sep. PMID 19716112.
Consequences of mutations within the C terminus of the FHL1 gene. Schoser B, et al. Neurology, 2009 Aug 18. PMID 19687455.
Four and a half LIM domains 1 (FHL1) and receptor interacting protein of 140kDa (RIP140) interact and cooperate in estrogen signaling. Lin J, et al. Int J Biochem Cell Biol, 2009 Jul. PMID 19401155.
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