|Application ||WB, E, EIA|
|Other Accession||NP_005896, 4093|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||52493 Da|
|Other Names||Mothers against decapentaplegic homolog 9, MAD homolog 9, Mothers against DPP homolog 9, Madh6, SMAD family member 9, SMAD 9, Smad9, SMAD9, MADH6, MADH9|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-SMAD9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).|
|Cellular Location||Cytoplasm. Nucleus. Note=In the cytoplasm in the absence of ligand Migration to the nucleus when complexed with SMAD4 (By similarity).|
|Tissue Location||Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells. Su D, et al. J Biol Chem, 2009 May 1. PMID 19269967.
Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells. Liu Y, et al. FASEB J, 2009 Jul. PMID 19244313.
A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension. Shintani M, et al. J Med Genet, 2009 May. PMID 19211612.
Holding their own: the noncanonical roles of Smad proteins. Hoover LL, et al. Sci Signal, 2008 Nov 18. PMID 19018011.
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