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Goat Anti-SMEK1 / KIAA2010 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-SMEK1 / KIAA2010 Antibody AF2007a
    AF2007a (0.3 µg/ml) staining of Human Pancreas lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • WB - Goat Anti-SMEK1 / KIAA2010 Antibody AF2007a
    HEK293 overexpressing SMEK1 (RC221040) and probed with AF2007a (mock transfection in first lane), tested by Origene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6IN85
Other Accession NP_115949, 55671, 68734 (mouse), 314388 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 95368 Da
Additional Information
Gene ID 55671
Other Names Serine/threonine-protein phosphatase 4 regulatory subunit 3A, SMEK homolog 1, SMEK1, KIAA2010, PP4R3A, PPP4R3A
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SMEK1 / KIAA2010 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMEK1
Synonyms KIAA2010, PP4R3A, PPP4R3A
Function Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions
Research Areas
Citations (0)

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PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. Chen GI, et al. J Biol Chem, 2008 Oct 24. PMID 18715871.
Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases. Martin-Granados C, et al. Int J Biochem Cell Biol, 2008. PMID 18487071.
Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects. Mendoza MC, et al. Mol Cell Biol, 2005 Sep. PMID 16107728.
A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Gingras AC, et al. Mol Cell Proteomics, 2005 Nov. PMID 16085932.

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$ 325.00
Cat# AF2007a
(40 western blots)
Availability: 7-10 days
Bulk Size
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