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Goat Anti-SMO (internal) Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-SMO (internal) Antibody AF2009b
    A) AF2009a and B) AF2009b (0.3 µg/ml) staining of Human Bone Marrow lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99835
Other Accession NP_005622, 6608, 319757 (mouse), 25273 (rat)
Reactivity Human
Predicted Mouse, Rat, Zebrafish, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 86397 Da
Additional Information
Gene ID 6608
Other Names Smoothened homolog, SMO, Protein Gx, SMO, SMOH
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SMO (internal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMO
Synonyms SMOH
Function G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.
Cellular Location Membrane; Multi-pass membrane protein. Cell projection, cilium
Research Areas
Citations (0)

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The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.


Immunohistochemical expression of SHH, PTC, SMO and GLI1 in glandular odontogenic cysts and dentigerous cysts. Zhang L, et al. Oral Dis, 2010 Jun 18. PMID 20561215.
Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. Walter K, et al. Clin Cancer Res, 2010 Mar 15. PMID 20215540.
Smoothened as a new therapeutic target for human osteosarcoma. Hirotsu M, et al. Mol Cancer, 2010 Jan 12. PMID 20067614.
Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin. Ritti茅 L, et al. Aging Cell, 2009 Dec. PMID 20050020.
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. Landa I, et al. PLoS Genet, 2009 Sep. PMID 19730683.

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$ 325.00
Cat# AF2009b
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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