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Goat Anti-SOCS7 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-SOCS7 Antibody AF2021a
    AF2021a (1 µg/ml) staining of Daudi lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14512
Other Accession NP_055413, 30837
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 62969 Da
Additional Information
Gene ID 30837
Other Names Suppressor of cytokine signaling 7, SOCS-7, Nck, Ash and phospholipase C gamma-binding protein, Nck-associated protein 4, NAP-4, SOCS7, NAP4, SOCS6
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SOCS7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOCS7
Synonyms NAP4, SOCS6
Function Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus Rapidly relocalizes to the nucleus after UV irradiation Cytoplasmic location depends upon SEPT7 presence
Tissue Location Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain
Research Areas
Citations (0)

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Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer. Sasi W, et al. BMC Cancer, 2010 Apr 30. PMID 20433750.
Hepatitis C virus core protein genotype 3a increases SOCS-7 expression through PPAR-{gamma} in Huh-7 cells. Pazienza V, et al. J Gen Virol, 2010 Jul. PMID 20357037.
Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. Kremer BE, et al. Cell, 2007 Sep 7. PMID 17803907.
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Zody MC, et al. Nature, 2006 Apr 20. PMID 16625196.
Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. Banks AS, et al. J Clin Invest, 2005 Sep. PMID 16127460.

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$ 325.00
Cat# AF2021a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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