Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
Goat Anti-SOD1 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E, EIA |
|---|---|
| Primary Accession | P00441 |
| Other Accession | NP_000445, 6647, 20655 (mouse), 24786 (rat) |
| Reactivity | Human, Mouse, Rat |
| Predicted | Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 15936 Da |
| Gene ID | 6647 |
|---|---|
| Other Names | Superoxide dismutase [Cu-Zn], 1.15.1.1, Superoxide dismutase 1, hSod1, SOD1 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-SOD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SOD1 (HGNC:11179) |
|---|---|
| Function | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. |
| Cellular Location | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
References
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. Laaksovirta H, et al. Lancet Neurol, 2010 Oct. PMID 20801718.
Knock-down of superoxide dismutase 1 sensitizes cisplatin-resistant human ovarian cancer cells. Kim JW, et al. Anticancer Res, 2010 Jul. PMID 20682985.
Genetics and clinical characteristics of keratoconus. Stabuc-Silih M, et al. Acta Dermatovenerol Alp Panonica Adriat, 2010. PMID 20664914.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis. Meissner F, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20616033.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
