|Application ||WB, E, EIA|
|Other Accession||NP_000445, 6647, 20655 (mouse), 24786 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||15936 Da|
|Other Names||Superoxide dismutase [Cu-Zn], 184.108.40.206, Superoxide dismutase 1, hSod1, SOD1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-SOD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|
|Cellular Location||Cytoplasm. Mitochondrion. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. Laaksovirta H, et al. Lancet Neurol, 2010 Oct. PMID 20801718.
Knock-down of superoxide dismutase 1 sensitizes cisplatin-resistant human ovarian cancer cells. Kim JW, et al. Anticancer Res, 2010 Jul. PMID 20682985.
Genetics and clinical characteristics of keratoconus. Stabuc-Silih M, et al. Acta Dermatovenerol Alp Panonica Adriat, 2010. PMID 20664914.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis. Meissner F, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20616033.
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