|Application ||WB, E|
|Other Accession||NP_003096, 6653|
|Predicted||Human, Rat, Dog, Cow|
|Calculated MW||248426 Da|
|Other Names||Sortilin-related receptor, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LDLR relative with 11 ligand-binding repeats, LR11, SorLA-1, Sorting protein-related receptor containing LDLR class A repeats, SorLA, SORL1, C11orf32|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-SORL1 / LR11 (C Terminus) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Golgi apparatus. Endosome Secreted|
|Tissue Location||Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. Expression is significantly reduced in the frontal cortex of patients suffering from Alzheimer disease. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.
Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population. Schuur M, et al. J Neurol Neurosurg Psychiatry, 2010 Jul 28. PMID 20667857.
Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels. Kauwe JS, et al. J Alzheimers Dis, 2010. PMID 20634593.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Amyloid-beta-Related Genes SORL1 and ACE are Genetically Associated With Risk for Late-onset Alzheimer Disease in the Chinese Population. Ning M, et al. Alzheimer Dis Assoc Disord, 2010 Jul 9. PMID 20625269.
Intermediate phenotypes identify divergent pathways to Alzheimer's disease. Shulman JM, et al. PLoS One, 2010 Jun 21. PMID 20574532.
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