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Goat Anti-SOX15 Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-SOX15 Antibody AF2027a
    AF2027a (0.1 µg/ml) staining of Human Muscle lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O60248
Other Accession NP_008873, 6665
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Additional Information
Other Names Protein SOX-15, Protein SOX-12, Protein SOX-20, SOX15, SOX12, SOX20, SOX26, SOX27
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SOX15 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX15
Synonyms SOX12, SOX20, SOX26, SOX27
Function Binds to the 5'-AACAAT-3' sequence.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267}
Tissue Location Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis. EMBL; AB006867; BAA25663.1; -; mRNA EMBL; AK301687; BAG63159.1; -; mRNA EMBL; AC016876; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471108; EAW90156.1; -; Genomic_DNA EMBL; CH471108; EAW90157.1; -; Genomic_DNA EMBL; BC000985; AAH00985.1; -; mRNA EMBL; BC072003; AAH72003.1; -; mRNA EMBL; X73039; CAA51520.1; -; Genomic_DNA EMBL; AJ006222; CAA06920.1; -; mRNA EMBL; AB025355; BAA78784.1; -; Genomic_DNA CCDS; CCDS32549.1; -. [O60248-1] PIR; S34119; S34119 RefSeq; NP_008873.1; NM_006942.1. [O60248-1] UniGene; Hs.95582; - ProteinModelPortal; O60248; - SMR; O60248; - BioGrid; 112548; 3 IntAct; O60248; 2 STRING; 9606.ENSP00000355354; - iPTMnet; O60248; - PhosphoSitePlus; O60248; - BioMuta; SOX15; - EPD; O60248; - MaxQB; O60248; - PaxDb; O60248; - PeptideAtlas; O60248; - PRIDE; O60248; - ProteomicsDB; 49282; - DNASU; 6665; - Ensembl; ENST00000250055; ENSP00000355354; ENSG00000129194. [O60248-1] Ensembl; ENST00000538513; ENSP00000439311; ENSG00000129194. [O60248-1] Ensembl; ENST00000570788; ENSP00000458286; ENSG00000129194. [O60248-2] GeneID; 6665; - KEGG; hsa:6665; - UCSC; uc002ghy.2; human. [O60248-1] CTD; 6665; - DisGeNET; 6665; - EuPathDB; HostDB:ENSG00000129194.7; - GeneCards; SOX15; - HGNC; HGNC:11196; SOX15 HPA; HPA067196; - HPA; HPA074049; - MIM; 601297; gene neXtProt; NX_O60248; - OpenTargets; ENSG00000129194; - PharmGKB; PA36033; - eggNOG; KOG0527; Eukaryota eggNOG; ENOG410XT0K; LUCA GeneTree; ENSGT00760000118988; - HOGENOM; HOG000231647; - HOVERGEN; HBG055512; - InParanoid; O60248; - KO; K09271; - OMA; YGSSHCK; - OrthoDB; EOG091G0M3O; - PhylomeDB; O60248; - TreeFam; TF351735; - GeneWiki; SOX15; - GenomeRNAi; 6665; - PRO; PR:O60248; - Proteomes; UP000005640; Chromosome 17 Bgee; ENSG00000129194; - CleanEx; HS_SOX12; - CleanEx; HS_SOX15; - Genevisible; O60248; HS GO; GO:0005737; C:cytoplasm; IEA:Ensembl GO; GO:0044798; C:nuclear transcription factor complex; IEA:Ensembl GO; GO:0005634; C:nucleus; NAS:UniProtKB GO; GO:0003682; F:chromatin binding; IEA:Ensembl GO; GO:0003677; F:DNA binding; NAS:UniProtKB GO; GO:0003700; F:DNA binding transcription factor activity; NAS:UniProtKB GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0030154; P:cell differentiation; ISS:BHF-UCL GO; GO:0006325; P:chromatin organization; NAS:UniProtKB GO; GO:0008584; P:male gonad development; TAS:ProtInc GO; GO:0048627; P:myoblast development; ISS:BHF-UCL GO; GO:0045843; P:negative regulation of striated muscle tissue development; ISS:BHF-UCL GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:BHF-UCL GO; GO:0070318; P:positive regulation of G0 to G1 transition; ISS:BHF-UCL GO; GO:2000288; P:positive regulation of myoblast proliferation; ISS:BHF-UCL GO; GO:0014718; P:positive regulation of satellite cell activation involved in skeletal muscle regeneration; ISS:BHF-UCL GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:BHF-UCL GO; GO:0006357; P:regulation of transcription by RNA polymerase II; TAS:ProtInc GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB GO; GO:0043403; P:skeletal muscle tissue regeneration; IEA:Ensembl Gene3D; 1.10.30.10; -; 1 InterPro; IPR009071; HMG_box_dom InterPro; IPR036910; HMG_box_dom_sf InterPro; IPR031269; SOX15 PANTHER; PTHR10270:SF45; PTHR10270:SF45; 1 Pfam; PF00505; HMG_box; 1 SMART; SM00398; HMG; 1 SUPFAM; SSF47095; SSF47095; 1 PROSITE; PS50118; HMG_BOX_2; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome CHAIN 1 233 Protein SOX-15 /FTId=PRO_0000048762 DNA_BIND 49 117 HMG box. {ECO:0000255|PROSITE- ProRule:PRU00267} MOD_RES 37 37 Phosphoserine VAR_SEQ 179 233 Missing (in isoform 2) /FTId=VSP_056668 CONFLICT 25 27 SSS -> AAA (in Ref. 6). CONFLICT 69 70 QQ -> HE (in Ref. 7; CAA51520) CONFLICT 191 191 S -> F (in Ref. 9; BAA78784) CONFLICT 216 218 PTP -> STS (in Ref. 9; BAA78784) CONFLICT 225 226 GA -> VP (in Ref. 9; BAA78784) SEQUENCE 233 AA; 25251 MW; 6B52AE455C7C8CCE CRC64; MALPGSSQDQ AWSLEPPAAT AAASSSSGPQ EREGAGSPAA PGTLPLEKVK RPMNAFMVWS SAQRRQMAQQ NPKMHNSEIS KRLGAQWKLL DEDEKRPFVE EAKRLRARHL RDYPDYKYRP RRKAKSSGAG PSRCGQGRGN LASGGPLWGP GYATTQPSRG FGYRPPSYST AYLPGSYGSS HCKLEAPSPC SLPQSDPRLQ GELLPTYTHY LPPGSPTPYN PPLAGAPMPL THL
Research Areas
Citations (0)

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Background

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.

References

Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies. Sakai N, et al. J Endocrinol, 2008 Sep. PMID 18579725.
Overexpression of SOX15 inhibits proliferation of NT2/D1 cells derived from a testicular embryonal cell carcinoma. Yan HT, et al. Mol Cells, 2007 Dec 31. PMID 18182846.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. Schepers GE, et al. Dev Cell, 2002 Aug. PMID 12194848.

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$ 335.00
Cat# AF2027a
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