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STAT3 (isoform 1 and 2) AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF2040a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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STAT3 (isoform 1 and 2) Antibody - Product info | |
| Other Accession | NP_644805 |
| Reactivity | Mouse |
| Concentration | 100ug/200ul |
| Isotype | IgG |
STAT3 (isoform 1 and 2) Antibody - Additional info | |
| Other Names STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); APRF; DNA-binding protein APRF; acute-phase response factor; FLJ20882; MGC16063; HIES | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions STAT3 (isoform 1 and 2) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
STAT3 (isoform 1 and 2) Antibody - Application data
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AF2040a (1 µg/ml) staining of NIH3T3 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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AF2040a overnight staining at 10ug/ml on 4%PFA-fixed mouse thymus. Subsequently labelled by Biotinylated mouse anti-goat IgG, and Streptavidin-AP. Stained with BCIP/NBT.
STAT3 (isoform 1 and 2) Antibody - Related products
AP1534a: Phospho-STAT3-S727 Antibody
AP3260a: Phospho-STAT3-S727 Antibody
AP3261a: Phospho-STAT3-Y705 Antibody
RI15110: STAT3 predesign siRNA
BP1534a: Phospho-STAT3-Ser727 Antibody Blocking Peptide
BP3260a: Phospho-STAT3-S727 Antibody Blocking Peptide
BP3261a: Phospho-STAT3-Y705 Blocking Peptide
AT4062a: STAT3 Antibody (monoclonal) (M02)
AJ1739c: Stat-3 Antibody Phospho (pS727)
AJ1739d: Stat-3 Antibody Phospho (pY705)
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BACKGROUND
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
REFERENCES
Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis. Schimke LF, et al. J Allergy Clin Immunol, 2010 Sep. PMID 20816194. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624. Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. Analysis of JAK2 and STAT3 polymorphisms in patients with ankylosing spondylitis in Chinese Han population. Chen C, et al. Clin Immunol, 2010 Sep. PMID 20627814.
