|Application ||WB, E|
|Other Accession||NP_078912, 79689, 117167 (mouse)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||51981 Da|
|Other Names||Metalloreductase STEAP4, 1.16.1.-, Six-transmembrane epithelial antigen of prostate 4, SixTransMembrane protein of prostate 2, Tumor necrosis factor, alpha-induced protein 9, STEAP4, STAMP2, TNFAIP9|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-STEAP4 / Dudulin4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.|
|Cellular Location||Cell membrane. Golgi apparatus membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Genetic variability at the six transmembrane protein of prostate 2 locus and the metabolic syndrome: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study. Miot A, et al. J Clin Endocrinol Metab, 2010 Jun. PMID 20382686.
STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes. Chen X, et al. Int J Mol Med, 2010 Mar. PMID 20127040.
STEAP4 regulates focal adhesion kinase activation and CpG motifs within STEAP4 promoter region are frequently methylated in DU145, human androgen-independent prostate cancer cells. Tamura T, et al. Int J Mol Med, 2009 Nov. PMID 19787193.
Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro. Kralisch S, et al. FEBS Lett, 2009 Apr 2. PMID 19289123.
Downregulation of STEAP4, a highly-expressed TNF-alpha-inducible gene in adipose tissue, is associated with obesity in humans. Zhang CM, et al. Acta Pharmacol Sin, 2008 May. PMID 18430367.
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