|Application ||WB, IHC, E|
|Other Accession||NP_037365, 27347, 53416 (mouse), 54348 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||59474 Da|
|Other Names||STE20/SPS1-related proline-alanine-rich protein kinase, Ste-20-related kinase, 18.104.22.168, DCHT, Serine/threonine-protein kinase 39, STK39, SPAK|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-STK39 / SPAK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation.|
|Cellular Location||Cytoplasm. Nucleus. Note=Nucleus when caspase-cleaved.|
|Tissue Location||Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.
Lack of association between polymorphisms in STK39, a putative thiazide response gene, and blood pressure response to hydrochlorothiazide. Duarte JD, et al. Pharmacogenet Genomics, 2010 Aug. PMID 20555294.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression. Cunnington MS, et al. BMC Med Genet, 2009 Dec 14. PMID 20003416.
Epigenetic silencing of Stk39 in B-cell lymphoma inhibits apoptosis from genotoxic stress. Balatoni CE, et al. Am J Pathol, 2009 Oct. PMID 19717643.
Renal and brain isoforms of WNK3 have opposite effects on NCCT expression. Glover M, et al. J Am Soc Nephrol, 2009 Jun. PMID 19470686.
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