|Application ||WB, E|
|Other Accession||NP_008960, 11075, 20257 (mouse)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||20828 Da|
|Other Names||Stathmin-2, Superior cervical ganglion-10 protein, Protein SCG10, STMN2, SCG10, SCGN10|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-STMN2 / SCG10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Golgi apparatus. Endosome. Cell projection, lamellipodium Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia.|
|Tissue Location||Neuron specific.|
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Provided below are standard protocols that you may find useful for product applications.
Superior cervical ganglion-10 is a neuronal growth-associated protein that shares significant amino acid sequence similarity with the phosphoprotein stathmin (MIM 151442).
Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study. Mead S, et al. Lancet Neurol, 2009 Jan. PMID 19081515.
Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10. Li YH, et al. J Biol Chem, 2009 Jan 2. PMID 18996843.
Stathmin-like 2, a developmentally-associated neuronal marker, is expressed and modulated during osteogenesis of human mesenchymal stem cells. Chiellini C, et al. Biochem Biophys Res Commun, 2008 Sep 12. PMID 18611392.
The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. Mahapatra NR, et al. Biochemistry, 2008 Jul 8. PMID 18549247.
BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells. Gong Y, et al. BMB Rep, 2008 Apr 30. PMID 18452648.
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