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Goat Anti-STS2 / TULA (internal) Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-STS2 / TULA (internal) Antibody AF2046a
    AF2046a (2.5 µg/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P57075
Other Accession NP_001001895, 53347
Reactivity Human
Predicted Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 74123 Da
Additional Information
Gene ID 53347
Other Names Ubiquitin-associated and SH3 domain-containing protein A, Cbl-interacting protein 4, CLIP4, Suppressor of T-cell receptor signaling 2, STS-2, T-cell ubiquitin ligand 1, TULA-1, UBASH3A, STS2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-STS2 / TULA (internal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms STS2
Function Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
Research Areas
Citations (0)

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Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis. Hinks A, et al. Ann Rheum Dis, 2010 Jul 20. PMID 20647273.
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. Jin Y, et al. N Engl J Med, 2010 May 6. PMID 20410501.
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Barrett JC, et al. Nat Genet, 2009 Jun. PMID 19430480.
Shared and distinct genetic variants in type 1 diabetes and celiac disease. Smyth DJ, et al. N Engl J Med, 2008 Dec 25. PMID 19073967.
Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. Grant SF, et al. Diabetes, 2009 Jan. PMID 18840781.

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$ 325.00
Cat# AF2046a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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