|Application ||WB, E|
|Other Accession||NP_443106, 6804, 112755, 20907 (mouse), 116470 (rat)|
|Predicted||Human, Rat, Dog, Cow|
|Calculated MW||33023 Da|
|Other Names||Syntaxin-1A, Neuron-specific antigen HPC-1, STX1A, STX1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-STX1A / STX1B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome|
|Tissue Location||Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 May 14. PMID 20471030.
Evidence of syntaxin 1A involvement in migraine susceptibility: a Portuguese study. Lemos C, et al. Arch Neurol, 2010 Apr. PMID 20385907.
Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. Yoshida T, et al. Int J Mol Med, 2009 Aug. PMID 19578796.
De novo STXBP1 mutations in mental retardation and nonsyndromic epilepsy. Hamdan FF, et al. Ann Neurol, 2009 Jun. PMID 19557857.
Contribution of syntaxin 1A to the genetic susceptibility to migraine: a case-control association study in the Spanish population. Corominas R, et al. Neurosci Lett, 2009 May 15. PMID 19368856.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.