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Goat Anti-SWAP70 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-SWAP70 Antibody AF2053a
    AF2053a (0.1 µg/ml) staining of Human Lymph Node lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UH65
Other Accession NP_055870, 23075
Reactivity Human
Predicted Mouse, Rat
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 68998 Da
Additional Information
Gene ID 23075
Other Names Switch-associated protein 70, SWAP-70, SWAP70, KIAA0640
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SWAP70 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SWAP70
Synonyms KIAA0640
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
Cellular Location Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia
Tissue Location Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus- associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760)
Research Areas
Citations (0)

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Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
Expression and localization of SWAP-70 in human fetomaternal interface and placenta during tubal pregnancy and normal placentation. Liu J, et al. J Histochem Cytochem, 2007 Jul. PMID 17371938.
Diagnostic surface expression of SWAP-70 on HIV-1 infected T cells. Kimbara N, et al. Microbiol Immunol, 2006. PMID 16547421.
Direct binding of SWAP-70 to non-muscle actin is required for membrane ruffling. Ihara S, et al. J Cell Sci, 2006 Feb 1. PMID 16418221.
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.

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$ 325.00
Cat# AF2053a
(40 western blots)
Availability: 7-10 days
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