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Synaptotagmin I Antibody

Peptide-affinity purified goat antibody

  •  - Synaptotagmin I Antibody AF2057a
    AF2057a (1µg/ml) staining of Human Hippocampus lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21579
Other Accession NP_005630, 6857, 20979 (mouse), 25716 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5mg/ml
Isotype IgG
Calculated MW 47573 Da
Additional Information
Gene ID 6857
Other Names Synaptotagmin-1, Synaptotagmin I, SytI, p65, SYT1, SVP65, SYT
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSynaptotagmin I Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYT1
Synonyms SVP65, SYT
Function May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Cellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules
Research Areas
Citations (0)

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The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).


Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level. Pattaro C, et al. BMC Med Genet, 2010 Mar 11. PMID 20222955.
Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1. Musch MW, et al. Am J Physiol Gastrointest Liver Physiol, 2010 Feb. PMID 19926819.
NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I-relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1). Kathir KM, et al. Biochim Biophys Acta, 2010 Feb. PMID 19835837.
De novo STXBP1 mutations in mental retardation and nonsyndromic epilepsy. Hamdan FF, et al. Ann Neurol, 2009 Jun. PMID 19557857.

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$ 325.00
Cat# AF2057a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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