|Application ||WB, E|
|Other Accession||NP_001007071, 6386, 53378 (mouse), 83841 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||32444 Da|
|Other Names||Syntenin-1, Melanoma differentiation-associated protein 9, MDA-9, Pro-TGF-alpha cytoplasmic domain-interacting protein 18, TACIP18, Scaffold protein Pbp1, Syndecan-binding protein 1, SDCBP, MDA9, SYCL|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Syntenin / SDCBP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1- mediated SMAD2/3 activation and TGFB1-induced epithelial-to- mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).|
|Cellular Location||Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Secreted, exosome. Membrane raft. Note=Mainly membrane-associated Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.|
|Tissue Location||Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
[Identification and expression of two new secretory proteins associated with prostate cancer] Qian XL, et al. Yi Chuan, 2010 Mar. PMID 20233700.
Src kinase activation is mandatory for MDA-9/syntenin-mediated activation of nuclear factor-kappaB. Boukerche H, et al. Oncogene, 2010 May 27. PMID 20228839.
Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin. Hwangbo C, et al. Cancer Res, 2010 Feb 15. PMID 20145126.
Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output. Beekman JM, et al. Blood, 2009 Oct 29. PMID 19654410.
A novel immunoregulatory protein in human colostrum, syntenin-1, for promoting the development of IgA-producing cells from cord blood B cells. Sira MM, et al. Int Immunol, 2009 Sep. PMID 19592421.
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