|Application ||WB, E|
|Other Accession||NP_061841, 54221|
|Calculated MW||60217 Da|
|Other Names||Gamma-2-syntrophin, G2SYN, Syntrophin-5, SYN5, SNTG2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Syntrophin gamma 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity).|
|Cellular Location||Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane|
|Tissue Location||Widely expressed. Strong expression in brain and testis. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein belonging to the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that bind to components of mechanosenstive sodium channels and the extreme carboxy-terminal domain of dystrophin and dystrophin-related proteins. The PDZ domain of this protein product interacts with a protein component of a mechanosensitive sodium channel that affects channel gating. Absence or reduction of this protein product has been associated with Duchenne muscular dystrophy. There is evidence of alternative splicing yet the full-length nature of these variants has not been described.
Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations. Yamakawa H, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17292328.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
Syntrophin gamma 2 regulates SCN5A gating by a PDZ domain-mediated interaction. Ou Y, et al. J Biol Chem, 2003 Jan 17. PMID 12429735.
Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013.
Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells. Piluso G, et al. J Biol Chem, 2000 May 26. PMID 10747910.
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