|Application ||WB, E|
|Other Accession||NP_851830, 6901|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||33459 Da|
|Other Names||Tafazzin, Protein G4.5, TAZ, EFE2, G4.5|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Tafazzin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Some isoforms may be involved in cardiolipin (CL) metabolism.|
|Cellular Location||Isoform 1: Membrane; Single-pass membrane protein Isoform 3: Membrane; Single-pass membrane protein Isoform 5: Membrane; Single-pass membrane protein Isoform 7: Membrane; Single-pass membrane protein Isoform 9: Cytoplasm.|
|Tissue Location||High levels in cardiac and skeletal muscle. Up to 10 isoforms can be present in different amounts in different tissues. Most isoforms are ubiquitous. Isoforms that lack the N- terminus are found in leukocytes and fibroblasts, but not in heart and skeletal muscle. Some forms appear restricted to cardiac and skeletal muscle or to leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known.
A novel custom resequencing array for dilated cardiomyopathy. Zimmerman RS, et al. Genet Med, 2010 May. PMID 20474083.
Human transcriptional coactivator with PDZ-binding motif (TAZ) is downregulated during decidualization. Strakova Z, et al. Biol Reprod, 2010 Jun. PMID 20164440.
Characterization of tafazzin splice variants from humans and fruit flies. Xu Y, et al. J Biol Chem, 2009 Oct 16. PMID 19700766.
Mutations in TAZ/WWTR1, a co-activator of NKX2.1 and PAX8 are not a frequent cause of thyroid dysgenesis. Ferrara AM, et al. J Endocrinol Invest, 2009 Mar. PMID 19542741.
TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. Zhang H, et al. J Biol Chem, 2009 May 15. PMID 19324877.
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