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Goat Anti-SM22 Alpha / Transgelin Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-SM22 Alpha / Transgelin Antibody AF2063a
    Transgelin staining of HeLa lysate (35 µg protein in RIPA buffer) by AF2063a (0.01 µg/ml). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01995
Other Accession NP_001001522, 6876, 21345 (mouse), 25123 (rat)
Reactivity Human, Mouse, Rat, Rabbit
Predicted Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 22611 Da
Additional Information
Gene ID 6876
Other Names Transgelin, 22 kDa actin-binding protein, Protein WS3-10, Smooth muscle protein 22-alpha, SM22-alpha, TAGLN, SM22, WS3-10
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SM22 Alpha / Transgelin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms SM22, WS3-10
Function Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.


Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
[A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer] Lisitskaia KV, et al. Mol Gen Mikrobiol Virusol, 2010. PMID 20540360.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Loss of SM22 is a characteristic signature of colon carcinogenesis and its restoration suppresses colon tumorigenicity in vivo and in vitro. Yeo M, et al. Cancer, 2010 Jun 1. PMID 20336793.
Transgelin induces apoptosis of human prostate LNCaP cells through its interaction with p53. Zhang ZW, et al. Asian J Androl, 2010 Mar. PMID 20098441.

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$ 325.00
Cat# AF2063a
(40 western blots)
Availability: 7-10 days
Bulk Size
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