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Goat Anti-Tankyrase 2 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Tankyrase 2 Antibody AF2066a
    AF2066a (0.5 µg/ml) staining of Jurkat lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H2K2
Other Accession NP_079511, 80351, 74493 (mouse)
Reactivity Human
Predicted Mouse, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 126918 Da
Additional Information
Gene ID 80351
Other Names Tankyrase-2, TANK2,, ADP-ribosyltransferase diphtheria toxin-like 6, ARTD6, Poly [ADP-ribose] polymerase 5B, TNKS-2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein, TNKS2, PARP5B, TANK2, TNKL
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Tankyrase 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNKS2
Synonyms PARP5B, TANK2, TNKL
Function Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.
Cellular Location Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1
Tissue Location Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain
Research Areas
Citations (0)

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Telomere length and genetic analyses in population-based studies of endometrial cancer risk. Prescott J, et al. Cancer, 2010 Sep 15. PMID 20549820.
New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.
Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis. Varadi V, et al. Eur J Cancer, 2009 Nov. PMID 19766477.
Isolation and physicochemical properties of tankyrase of human embryonic kidney cells of line 293. Sidorova NN, et al. Biochemistry (Mosc), 2008 Mar. PMID 18393764.
Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients. Shebzukhov YV, et al. Cancer Immunol Immunother, 2008 Jun. PMID 18026951.

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$ 325.00
Cat# AF2066a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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