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Goat Anti-TBL1X / TBL1XR1 Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-TBL1X / TBL1XR1 Antibody AF2069a
    AF2069a (4µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60907
Other Accession NP_078941, 6907, 79718
Reactivity Human
Predicted Mouse, Rat, Cow, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 62496 Da
Additional Information
Gene ID 6907
Other Names F-box-like/WD repeat-containing protein TBL1X, SMAP55, Transducin beta-like protein 1X, Transducin-beta-like protein 1, X-linked, TBL1X, TBL1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-TBL1X / TBL1XR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TBL1X
Synonyms TBL1
Function F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
Cellular Location Nucleus.
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.


TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. Perissi V, et al. Mol Cell, 2008 Mar 28. PMID 18374649.
Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment. Ishii S, et al. Proc Natl Acad Sci U S A, 2008 Mar 18. PMID 18326024.
TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Li J, et al. Nat Cell Biol, 2008 Feb. PMID 18193033.
Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization. Gerlitz G, et al. Cell Cycle, 2005 Nov. PMID 16258276.
Reading and function of a histone code involved in targeting corepressor complexes for repression. Yoon HG, et al. Mol Cell Biol, 2005 Jan. PMID 15601853.

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$ 325.00
Cat# AF2069a
(40 western blots)
Availability: 7-10 days
Bulk Size
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