|Application ||WB, ICC, E|
|Other Accession||NP_006472, 6928, 21410 (mouse), 25640 (rat)|
|Predicted||Mouse, Rat, Zebrafish, Pig, Dog, Cow|
|Calculated MW||61324 Da|
|Other Names||Hepatocyte nuclear factor 1-beta, HNF-1-beta, HNF-1B, Homeoprotein LFB3, Transcription factor 2, TCF-2, Variant hepatic nuclear factor 1, vHNF1, HNF1B, TCF2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-TCF2 / VHNF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Meta-analysis of genome-wide and replication association studies on prostate cancer. Liu H, et al. Prostate, 2010 Aug 5. PMID 20690139.
COMMON VARIANTS IN 40 GENES ASSESSED FOR DIABETES INCIDENCE AND RESPONSE TO METFORMIN AND LIFESTYLE INTERVENTIONS IN THE DIABETES PREVENTION PROGRAM. Jablonski KA, et al. Diabetes, 2010 Aug 3. PMID 20682687.
Mutations in the hepatocyte nuclear factor-1beta (HNF1B) gene are common with combined uterine and renal malformations but are not found with isolated uterine malformations. Oram RA, et al. Am J Obstet Gynecol, 2010 Jul 14. PMID 20633866.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Number of prostate cancer risk alleles may identify possibly 'insignificant' disease. Helfand BT, et al. BJU Int, 2010 Jun 30. PMID 20590552.
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