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Goat Anti-TCP1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-TCP1 Antibody AF2076a
    AF2076a staining (1 µg/ml) of Human Lung lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
  • IHC - Goat Anti-TCP1 Antibody AF2076a
    AF2076a (10 µg/ml) staining of paraffin embedded Human Testis. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17987
Other Accession NP_001008897, 6950
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 60344 Da
Additional Information
Gene ID 6950
Other Names T-complex protein 1 subunit alpha, TCP-1-alpha, CCT-alpha, TCP1, CCT1, CCTA
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-TCP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TCP1
Synonyms CCT1, CCTA
Function Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Research Areas
Citations (0)

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The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found.


Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes. Mukherjee K, et al. BMC Evol Biol, 2010 Mar 1. PMID 20193073.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
Functions of membrane binding domain of CTP:phosphocholine cytidylyltransferase in alveolar type II cells. Ridsdale R, et al. Am J Respir Cell Mol Biol, 2010 Jul. PMID 19684306.
A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. Burgner D, et al. PLoS Genet, 2009 Jan. PMID 19132087.

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$ 325.00
Cat# AF2076a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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