|Application ||WB, E|
|Other Accession||NP_005876, 10299, 223455 (mouse)|
|Calculated MW||102545 Da|
|Other Names||E3 ubiquitin-protein ligase MARCH6, 6.3.2.-, Doa10 homolog, Membrane-associated RING finger protein 6, Membrane-associated RING-CH protein VI, MARCH-VI, Protein TEB-4, RING finger protein 176, MARCH6, KIAA0597, RNF176, TEB4|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-TEB4 / MARCH-VI (aa 701 to 712) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0597, RNF176, TEB4|
|Function||E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Present in brain (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
MARCH6 is an E3 ubiquitin (see MIM 191339) ligase that localizes to endoplasmic reticulum (ER) membranes (Hassink et al., 2005 [PubMed 15673284]).
The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. Zavacki AM, et al. Mol Cell Biol, 2009 Oct. PMID 19651899. Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). Kreft SG, et al. J Biol Chem, 2006 Feb 24. PMID 16373356. TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum. Hassink G, et al. Biochem J, 2005 Jun 1. PMID 15673284. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. Bartee E, et al. J Virol, 2004 Feb. PMID 14722266.
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