|Application ||WB, E|
|Other Accession||NP_004604, 7052|
|Calculated MW||77329 Da|
|Other Names||Protein-glutamine gamma-glutamyltransferase 2, 220.127.116.11, Tissue transglutaminase, Transglutaminase C, TG(C), TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase-2, TGase-2, TGM2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-TGM2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.|
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Provided below are standard protocols that you may find useful for product applications.
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway. Kim DS, et al. Biochem Biophys Res Commun, 2010 Aug 20. PMID 20659425.
Redox regulation of transglutaminase 2 activity. Stamnaes J, et al. J Biol Chem, 2010 Aug 13. PMID 20547769.
Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness. Santhanam L, et al. Circ Res, 2010 Jul 9. PMID 20489165.
Coeliac disease autoantibodies mediate significant inhibition of tissue transglutaminase. Byrne G, et al. Clin Immunol, 2010 Sep. PMID 20488756.
Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5. Frese-Schaper M, et al. FEBS Lett, 2010 Jul 2. PMID 20450916.
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