|Application ||WB, E|
|Other Accession||NP_071505, 7072, 21841 (mouse), 312510 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||42963 Da|
|Other Names||Nucleolysin TIA-1 isoform p40, RNA-binding protein TIA-1, T-cell-restricted intracellular antigen-1, TIA-1, p40-TIA-1, TIA1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-TIA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.|
|Cellular Location||Cytoplasmic granule. Nucleus Note=Accumulates in cytoplasmic stress granules (SG) following cellular damage.|
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Provided below are standard protocols that you may find useful for product applications.
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors. Milne K, et al. PLoS One, 2009 Jul 29. PMID 19641607.
Sam68 relocalization into stress granules in response to oxidative stress through complexing with TIA-1. Henao-Mejia J, et al. Exp Cell Res, 2009 Nov 15. PMID 19615357.
Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases. Furukawa Y, et al. J Neurosci, 2009 Apr 22. PMID 19386911.
TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2. Yeowell HN, et al. J Invest Dermatol, 2009 Jun. PMID 19110540.
Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival. Eisinger-Mathason TS, et al. Mol Cell, 2008 Sep 5. PMID 18775331.
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