|Application ||WB, E|
|Other Accession||NP_001001563, 92609|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||39646 Da|
|Other Names||Mitochondrial import inner membrane translocase subunit TIM50, TIMM50, TIM50|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-TIM50 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body.|
|Cellular Location||Mitochondrion inner membrane; Single-pass membrane protein|
|Tissue Location||Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.
Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis. Xu H, et al. BMC Cell Biol, 2005 Jul 11. PMID 16008839.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. Guo Y, et al. J Biol Chem, 2004 Jun 4. PMID 15044455.
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