|Application ||WB, E|
|Other Accession||NP_001091993, 10553|
|Calculated MW||27049 Da|
|Other Names||Oxidoreductase HTATIP2, 1.1.1.-, 30 kDa HIV-1 TAT-interacting protein, HIV-1 TAT-interactive protein 2, HTATIP2 (HGNC:16637)|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-TIP30 / CC3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.|
|Cellular Location||Cytoplasm. Nucleus envelope|
|Tissue Location||Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CC3/TIP30 affects DNA damage repair. Fong S, et al. BMC Cell Biol, 2010 Apr 7. PMID 20374651.
Factors that retard remyelination in multiple sclerosis with a focus on TIP30: a novel therapeutic target. Nakahara J, et al. Expert Opin Ther Targets, 2009 Dec. PMID 19839715.
Expression of TIP30 tumor suppressor gene is down-regulated in human colorectal carcinoma. Chen X, et al. Dig Dis Sci, 2010 Aug. PMID 19798571.
Decreased TIP30 expression promotes tumor metastasis in lung cancer. Tong X, et al. Am J Pathol, 2009 May. PMID 19349353.
Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis. Nakahara J, et al. J Clin Invest, 2009 Jan. PMID 19104151.
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