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Goat Anti-Tissue Factor Pathway Inhibitor Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Tissue Factor Pathway Inhibitor Antibody AF2093a
    HEK293 overexpressing TFPI (RC219033) and probed with AF2093a (mock transfection in first lane), tested by Origene.
  • WB - Goat Anti-Tissue Factor Pathway Inhibitor Antibody AF2093a
    AF2093a staining (0.3 µg/ml) of Hela lysate (RIPA buffer, 35 µg total protein cells per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10646
Other Accession NP_006278, 7035
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 35015 Da
Additional Information
Gene ID 7035
Other Names Tissue factor pathway inhibitor, TFPI, Extrinsic pathway inhibitor, EPI, Lipoprotein-associated coagulation inhibitor, LACI, TFPI, LACI, TFPI1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Tissue Factor Pathway Inhibitor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms LACI, TFPI1
Function Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Cellular Location Isoform Alpha: Secreted.
Tissue Location Mostly in endothelial cells.
Research Areas
Citations (0)

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This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.


Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Functional characterization of polymorphisms in the human TFPI gene. Skretting G, et al. Biochem Biophys Res Commun, 2010 Jun 18. PMID 20519147.
Tissue factor pathway inhibitor polymorphisms in women with and without a history of venous thrombosis and the effects of postmenopausal hormone therapy. Opstad TB, et al. Blood Coagul Fibrinolysis, 2010 Sep. PMID 20453636.
Gender differences of polymorphisms in the TF and TFPI genes, as related to phenotypes in patients with coronary heart disease and type-2 diabetes. Opstad TB, et al. Thromb J, 2010 May 5. PMID 20444258.
Gene variants associated with venous thrombosis: confirmation in the MEGA study. Arellano AR, et al. J Thromb Haemost, 2010 May. PMID 20128871.

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$ 325.00
Cat# AF2093a
(40 western blots)
Availability: 7-10 days
Bulk Size
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