|Application ||WB, E|
|Other Accession||NP_004607, 7103|
|Calculated MW||26044 Da|
|Other Names||Tetraspanin-8, Tspan-8, Transmembrane 4 superfamily member 3, Tumor-associated antigen CO-029, TSPAN8, TM4SF3|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-TM4SF3 / TSPAN8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Gastric, colon, rectal, and pancreatic carcinomas|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.
Obesity and diabetes genetic variants associated with gestational weight gain. Stuebe AM, et al. Am J Obstet Gynecol, 2010 Sep. PMID 20816152.
Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. Fontaine-Bisson B, et al. Diabetologia, 2010 Oct. PMID 20571754.
Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight. Andersson EA, et al. Diabetologia, 2010 Sep. PMID 20490451.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Wellcome Trust Case Control Consortium, et al. Nature, 2010 Apr 1. PMID 20360734.
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