|Application ||WB, E|
|Other Accession||NP_005477, 10040|
|Calculated MW||52989 Da|
|Other Names||TOM1-like protein 1, Src-activating and signaling molecule protein, Target of Myb-like protein 1, TOM1L1, SRCASM|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-TOM1L1 / SRCASM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).|
|Cellular Location||Golgi apparatus, Golgi stack. Endosome membrane. Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=A small proportion is membrane-associated.|
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Provided below are standard protocols that you may find useful for product applications.
TOM1L is involved in a novel signaling pathway important for the IL-2 production in Jurkat T cells stimulated by CD3/CD28 co-ligation. Elmarghani A, et al. Mediators Inflamm, 2009. PMID 20182632.
Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor. Liu NS, et al. EMBO J, 2009 Nov 18. PMID 19798056.
Decreased Srcasm expression in hyperproliferative cutaneous lesions. Meulener MC, et al. J Cutan Pathol, 2009 Mar. PMID 19220627.
Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. Thalappilly S, et al. Proteomics, 2008 Aug. PMID 18654987.
Recruitment of Tom1L1/Srcasm to endosomes and the midbody by Tsg101. Yanagida-Ishizaki Y, et al. Cell Struct Funct, 2008. PMID 18367816.
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