|Application ||WB, E|
|Other Accession||NP_001003397, 7164|
|Calculated MW||22449 Da|
|Other Names||Tumor protein D53, hD53, Tumor protein D52-like 1, TPD52L1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-TPD52L1 / D53 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined.
A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. Cao Q, et al. Biochem Biophys Res Commun, 2006 Jun 9. PMID 16631610.
Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations. Barbaric D, et al. Leuk Res, 2006 Nov. PMID 16620967.
A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.
D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells. Boutros R, et al. Exp Cell Res, 2005 Oct 15. PMID 16112108.
Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1. Cho S, et al. J Biol Chem, 2004 Apr 16. PMID 14761963.
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