|Application ||WB, IHC, E|
|Other Accession||NP_001152759, 7167|
|Predicted||Rat, Dog, Cow|
|Calculated MW||30791 Da|
|Other Names||Triosephosphate isomerase, TIM, 220.127.116.11, Triose-phosphate isomerase, TPI1, TPI|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Triosephosphate isomerase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants.
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 May 14. PMID 20471030. Triose phosphate isomerase deficiency associated with two novel mutations in TPI gene. Fermo E, et al. Eur J Haematol, 2010 Aug. PMID 20374271. [Identification and expression of two new secretory proteins associated with prostate cancer] Qian XL, et al. Yi Chuan, 2010 Mar. PMID 20233700. Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation. Martins-de-Souza D, et al. BMC Psychiatry, 2009 Apr 30. PMID 19405953. Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples. Manco L, et al. Am J Hum Biol, 2009 Jan-Feb. PMID 18792062.
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