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TRPM7 / LTRPC7 AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF2117a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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TRPM7 / LTRPC7 Antibody - Product info | |
| Other Accession | NP_060142 |
| Reactivity | Human |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
TRPM7 / LTRPC7 Antibody - Additional info | |
| Other Names TRPM7; transient receptor potential cation channel, subfamily M, member 7; CHAK; CHAK1; LTRPC7; FLJ20117; TRP-PLIK; LTRPC ion channel family member 7; homolog of mouse transient receptor potential-phospholipase C-interacting kinase CHaK hypothetical protein FLJ20117; FLJ25718 | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions TRPM7 / LTRPC7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
TRPM7 / LTRPC7 Antibody - Application data
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AF2117a (0.5 µg/ml) staining of Human Cerebellum lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
TRPM7 / LTRPC7 Antibody - Related products
AP8052a: TRPM7 (CHAK1) Antibody (N-term)
AP8052b: TRPM7 (CHAK1) Antibody (C-term)
RI15481: TRPM7 predesign siRNA
BP8052a: CHAK1 Antibody (N-term) Blocking Peptide
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BACKGROUND
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.
REFERENCES
TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation. Du J, et al. Circ Res, 2010 Mar 19. PMID 20075334. TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase. Su LT, et al. J Mol Biol, 2010 Mar 5. PMID 20070945. Identification of TRPM7 channels in human intestinal interstitial cells of Cajal. Kim BJ, et al. World J Gastroenterol, 2009 Dec 14. PMID 19998500. Gene variation of the transient receptor potential cation channel, subfamily M, member 7 (TRPM7), and risk of incident ischemic stroke: prospective, nested, case-control study. Romero JR, et al. Stroke, 2009 Sep. PMID 19644062. Evidence that TRPM7 is required for breast cancer cell proliferation. Guilbert A, et al. Am J Physiol Cell Physiol, 2009 Sep. PMID 19515901.