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Goat Anti-TSPO / PBR (isoform) Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-TSPO / PBR (isoform) Antibody AF2121a
    AF2121a (0.1 µg/ml) staining of Human Breast Cancer lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • IHC - Goat Anti-TSPO / PBR (isoform) Antibody AF2121a
    AF2121a (2.5 µg/ml) staining of paraffin embedded Human Colon. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P30536
Other Accession NP_000705, 706
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 18828 Da
Additional Information
Gene ID 706
Other Names Translocator protein, Mitochondrial benzodiazepine receptor, PKBS, Peripheral-type benzodiazepine receptor, PBR, TSPO, BZRP, MBR
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-TSPO / PBR (isoform) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms BZRP, MBR
Function Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678).
Cellular Location Mitochondrion membrane; Multi-pass membrane protein
Tissue Location Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.
Research Areas
Citations (0)

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Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.


Oral cancer, cigarette smoke and mitochondrial 18kDa translocator protein (TSPO) - In vitro, in vivo, salivary analysis. Nagler R, et al. Biochim Biophys Acta, 2010 May. PMID 20085808.
The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals. Costa B, et al. Endocrinology, 2009 Dec. PMID 19846611.
Translocator protein blockade reduces prostate tumor growth. Fafalios A, et al. Clin Cancer Res, 2009 Oct 1. PMID 19789311.
Genetic susceptibility to distinct bladder cancer subphenotypes. Guey LT, et al. Eur Urol, 2010 Feb. PMID 19692168.
Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression. Costa B, et al. Psychiatr Genet, 2009 Apr. PMID 19668118.

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$ 325.00
Cat# AF2121a
(40 western blots)
Availability: 7-10 days
Bulk Size
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