|Application ||WB, E|
|Other Accession||NP_000574, 2638|
|Calculated MW||52964 Da|
|Other Names||Vitamin D-binding protein, DBP, VDB, Gc-globulin, Group-specific component, GC|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Vitamin D-binding protein / GC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues.
Association of vitamin D binding protein variants with susceptibility to chronic obstructive pulmonary disease. Shen LH, et al. J Int Med Res, 2010 May-Jun. PMID 20819447.
Vitamin D-binding protein polymorphisms are not associated with development of (multiple) basal cell carcinomas. Flohil SC, et al. Exp Dermatol, 2010 Aug 31. PMID 20812960.
High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density. Giroux S, et al. Bone, 2010 Jul 30. PMID 20654748.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Silva LK, et al. Eur J Hum Genet, 2010 Jun 30. PMID 20588308.
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