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Goat Anti-VMAT2 / SLC18A2 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-VMAT2 / SLC18A2 Antibody AF2148a
    AF2148a (0.3 µg/ml) staining of Human Placenta lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • IHC - Goat Anti-VMAT2 / SLC18A2 Antibody AF2148a
    AF2148a (2.5 µg/ml) staining of paraffin embedded Human Adrenal Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q05940
Other Accession NP_003045, 6571, 214084 (mouse), 25549 (rat)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 55713 Da
Additional Information
Gene ID 6571
Other Names Synaptic vesicular amine transporter, Monoamine transporter, Solute carrier family 18 member 2, Vesicular amine transporter 2, VAT2, SLC18A2, SVMT, VMAT2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-VMAT2 / SLC18A2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC18A2
Synonyms SVMT, VMAT2
Function Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.
Cellular Location Cytoplasmic vesicle membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).


An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.
Association study of 182 candidate genes in anorexia nervosa. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life. Lin Z, et al. FASEB J, 2010 Jul. PMID 20181938.
In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133. Okamura N, et al. J Nucl Med, 2010 Feb. PMID 20080893.

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$ 325.00
Cat# AF2148a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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