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VMAT2 / SLC18A2 AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF2148a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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VMAT2 / SLC18A2 Antibody - Product info | |
| Other Accession | NP_003045 |
| Reactivity | Human |
| Concentration | 100ug/200ul |
| Isotype | IgG |
VMAT2 / SLC18A2 Antibody - Additional info | |
| Other Names SLC18A2; VMAT2; SVAT; SVMT; VAT2; solute carrier family 18 (vesicular monoamine), member 2; MGC120477; MGC120478; MGC26538 | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions VMAT2 / SLC18A2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
VMAT2 / SLC18A2 Antibody - Application data
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AF2148a (0.3 µg/ml) staining of Human Placenta lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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AF2148a (2.5 µg/ml) staining of paraffin embedded Human Adrenal Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
VMAT2 / SLC18A2 Antibody - Related products
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BACKGROUND
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).
REFERENCES
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014. Association study of 182 candidate genes in anorexia nervosa. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life. Lin Z, et al. FASEB J, 2010 Jul. PMID 20181938. In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133. Okamura N, et al. J Nucl Med, 2010 Feb. PMID 20080893.
