|Application ||WB, E|
|Other Accession||NP_006361, 10490, 53612 (mouse)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||26688 Da|
|Other Names||Vesicle transport through interaction with t-SNAREs homolog 1B, Vesicle transport v-SNARE protein Vti1-like 1, Vti1-rp1, VTI1B, VTI1, VTI1L, VTI1L1, VTI2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-VTI1B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||VTI1, VTI1L, VTI1L1, VTI2|
|Function||V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.|
|Cellular Location||Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane. Cytoplasmic granule|
|Tissue Location||Expressed in all tissues examined.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. Furuta N, et al. Mol Biol Cell, 2010 Mar. PMID 20089838.
Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells. Bilan F, et al. Exp Cell Res, 2008 Jul 1. PMID 18570918.
Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.
A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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