|Application ||WB, E|
|Other Accession||NP_110388, 54361, 22417 (mouse)|
|Calculated MW||39052 Da|
|Other Names||Protein Wnt-4, WNT4|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-WNT4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese. Uno S, et al. Nat Genet, 2010 Aug. PMID 20601957.
Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence. Kvell K, et al. PLoS One, 2010 May 18. PMID 20502698.
The unappreciated Wnt-4 gene. Altchek A, et al. J Pediatr Adolesc Gynecol, 2010 Jun. PMID 20060343.
WNT4 is expressed in human fetal and adult ovaries and its signaling contributes to ovarian cell survival. J脌脌skel脌inen M, et al. Mol Cell Endocrinol, 2010 Apr 12. PMID 19962424.
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