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Goat Anti-Ymer / CCDC50 Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-Ymer / CCDC50 Antibody AF2167a
    AF2167a (5 µg/ml) staining of paraffin embedded Human Pancreas. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IVM0
Other Accession NP_777568, 152137
Reactivity Human
Predicted Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 35822 Da
Additional Information
Gene ID 152137
Other Names Coiled-coil domain-containing protein 50, Protein Ymer, CCDC50, C3orf6
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Ymer / CCDC50 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCDC50
Synonyms C3orf6
Function Involved in EGFR signaling.
Cellular Location Cytoplasm. Note=Associated with microtubules of the cytoskeleton and mitotic apparatus.
Tissue Location Isoform 1 and isoform 2 are coexpressed in placenta, liver, lung, kidney and pancreas. Only isoform 1 is detected in skeletal muscle, brain and heart
Research Areas
Citations (0)

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This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms.


Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia. Farfsing A, et al. Leukemia, 2009 Nov. PMID 19641524.
Inhibition of NF-kappaB signaling via tyrosine phosphorylation of Ymer. Kameda H, et al. Biochem Biophys Res Commun, 2009 Jan 23. PMID 19059208.
Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain. Bohgaki M, et al. Biochim Biophys Acta, 2008 May. PMID 18029035.
A mutation in CCDC50, a gene encoding an effector of epidermal growth factor-mediated cell signaling, causes progressive hearing loss. Modamio-Hoybjor S, et al. Am J Hum Genet, 2007 Jun. PMID 17503326.

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$ 325.00
Cat# AF2167a
(40 western blots)
Availability: 7-10 days
Bulk Size
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