|Application ||WB, E|
|Other Accession||NP_037505, 29801, 27801 (mouse), 303796 (rat)|
|Predicted||Mouse, Rat, Pig, Dog|
|Calculated MW||81443 Da|
|Other Names||Probable palmitoyltransferase ZDHHC8, 22.214.171.124, Zinc finger DHHC domain-containing protein 8, DHHC-8, Zinc finger protein 378, ZDHHC8, KIAA1292, ZDHHCL1, ZNF378|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ZDHHC8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1292, ZDHHCL1, ZNF378|
|Function||Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.|
|Cellular Location||Cytoplasmic vesicle membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.
Testing for genetic association between the ZDHHC8 gene locus and susceptibility to schizophrenia: An integrated analysis of multiple datasets. Xu M, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 May 24. PMID 20661937.
Association of ZDHHC8 polymorphisms with smooth pursuit eye movement abnormality. Shin HD, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Sep. PMID 20468065.
Association study of 182 candidate genes in anorexia nervosa. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064.
Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes. Yang W, et al. Mol Cell Proteomics, 2010 Jan. PMID 19801377.
Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function. Singaraja RR, et al. Circ Res, 2009 Jul 17. PMID 19556522.
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