Goat Anti-ZDHHC8 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9ULC8 |
Other Accession | NP_037505, 29801, 27801 (mouse), 303796 (rat) |
Reactivity | Human |
Predicted | Mouse, Rat, Pig, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 100ug/200ul |
Isotype | IgG |
Calculated MW | 81443 Da |
Gene ID | 29801 |
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Other Names | Probable palmitoyltransferase ZDHHC8, 2.3.1.225, Zinc finger DHHC domain-containing protein 8, DHHC-8, Zinc finger protein 378, ZDHHC8, KIAA1292, ZDHHCL1, ZNF378 |
Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-ZDHHC8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZDHHC8 (HGNC:18474) |
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Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). |
Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane {ECO:0000250|UniProtKB:Q5Y5T5}; Multi-pass membrane protein |
Tissue Location | Widely expressed.. |
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Background
This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.
References
Testing for genetic association between the ZDHHC8 gene locus and susceptibility to schizophrenia: An integrated analysis of multiple datasets. Xu M, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 May 24. PMID 20661937.
Association of ZDHHC8 polymorphisms with smooth pursuit eye movement abnormality. Shin HD, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Sep. PMID 20468065.
Association study of 182 candidate genes in anorexia nervosa. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064.
Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes. Yang W, et al. Mol Cell Proteomics, 2010 Jan. PMID 19801377.
Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function. Singaraja RR, et al. Circ Res, 2009 Jul 17. PMID 19556522.
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